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KMID : 0362720150530070485
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Journal of the Korean Dental Association
2015 Volume.53 No. 7 p.485 ~ p.499
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Delayed intentional replantation: new approach for periodontal regeneration and establishment of theoretical background
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Kim You-Kyoung
Kim Dong-Ju
Lee Eun-Ung
Lim Hyun-Chang
Lee Jung-Seok
Jung Ui-Won
Yun Jeong-Ho
Kim Eui-Seong
Lee Seung-Jong
Choi Seong-Ho
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Abstract
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Purpose: Delayed intentional replantation was introduced as a new alternative to treat the teeth with severe periodontal involvement. The purpose of this study was to elucidate the possibility of delayed intentional replantation and establish theoretical backgrounds.
Materials and Methods: Studies were performed into the following two subjects; Clinical evaluation of patients who underwent delayed intentional replantation using clinical and radiographic data. Severe periodontitis involved teeth were carefully extracted and proper time for delayed replantation was evaluated by analyzing inflammation markers (IL-6, TNF- ). Theoretical studies for efficacy of delayed intentional replantation using (-)-Epigallocatechin-3-gallate (EGCG) for preservation of periodontal ligament cells on root surface by minimizing inflammation and treatment of inflammatory extraction sockets.
Results: Meaningful success ratio and survival rate were found in delayed intentional replantation showing reduced bone loss and maintained bone level. Additionally, viability of EGCG applied periodontal ligament cells was much higher than control group. Also, EGCG promoted healing of inflammatory extraction sockets by inhibiting inflammatory cell proliferation.
Conclusion: Within the limitations of this study, 1-2 weeks after extraction is an appropriate time to do delayed intentional
replantation. Also, EGCG provides helpful effects on viability of periodontal ligament cells and periodontium.
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KEYWORD
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Delayed intentional replantation, Tooth extraction, Periodontitis, (-)-Epigallocatechin-3-gallate (EGCG), Anti-inflammatory effect
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